Research: GIST Support UK funded research projects/awards and other GSUK associated projects.

GSUK is focused on stimulating research to improve treatments and find a cure for GIST cancer.
This aim is only made possible with the funds raised by our supporters and the dedicated researchers who work with us.

Wildtype SDH Deficient GIST in the UK; A review of clinical course, genetics, epigenetics and metabolomics.

Dr Ruth Casey

Principal investigator (PI) - Dr Ruth Casey
Funding awarded by GSUK - £60,000
Project Duration - 3rd January 2017  to 31st December 2020.
Research outputs: TBC

 

Next generation sequencing of WT GIST's to identify therapeutic targets.

Dr Newton Wong

Principal investigator (PI) - Dr Newton Wong
Funding awarded by GSUK - £15,389
Project Duration - 1st July 2017 - ongoing
Research outputs: TBC

Derivation, maintenance and characterisation of cell lines from biopsies of PAWS-GIST.

Dr Karen Sisley

Principal investigator (PI) - Dr Karen Sisley
Funding awarded by GSUK - £15,180
Project Duration - 1st August 2016 - ongoing
Research outputs: TBC

SSGXXII Scandinavian 3 versus 5 years adjuvant imatinib study - contribution towards patient travel expenses.

Dr V.Ramesh Bulusu

Principal investigator (PI) - Dr V.Ramesh Bulusu
Funding awarded by GSUK - £6,000
Project Duration - 1st january 2018 - for 5 years
Research outputs: TBC

SSGXXII Scandinavian 3 versus 5 years adjuvant imatinib study - funding to extend the UK trial for 1 year until March 2020 enabling the recruitment of a further 20 GIST patients in the UK.

Dr V.Ramesh Bulusu

Principal investigator (PI) - Dr V.Ramesh Bulusu
Funding awarded by GSUK - £22,800
Project Duration - 1st April 2019 - March 2020
Research outputs: TBC

Research to investigate the potential of Gallium-68 (68Ga) DOTA-conjugated peptidePET/CT to develop theranostic applications in wild-type gastrointestinal stromal tumours (GISTs).

Dr Ruth Casey

Principal investigator (PI) - Dr Ruth Casey
Funding awarded by GSUK - £21,000
Project Duration - Starting in 2019
Research outputs: TBC

Pilot Study - Altered RNA methylation in SDH deficient gastrointestinal stromal tumours

Dr Olivier Giger

Principal investigator (PI) - Dr Olivier Giger
Funding awarded by GSUK - £7,000
Project Duration - Starting in March 2019
Research outputs: TBC

Metabolic alterations and vulnerabilities of succinate dehydrogenase-deficient GIST

Professor Eyal Gottlieb

Principal investigator (PI) - Professor Eyal Gottlieb
Funding awarded by GSUK - £Zero (Tissue supplied by National GIST Tissue Bank)
Project Duration - Commenced 2018
Research outputs: TBC

Collection of GIST tissue samples stored in hospital pathology departments for patients who had been treated at the Marsden over previous years, then retrospectively undertake mutational analysis of all the samples.

Professor Ian Judson

Principal investigator (PI) - Professor Ian Judson
Funding awarded by GSUK - £20,000
Project Duration - Commenced 2016
Research outputs: Professor Judson is excited to report that with GIST Support UK’s help, he and his team managed, to “accumulate a database of clinical and mutational analysis information on 550 GIST patients”.  This material will form the basis for a research project, in collaboration with other groups, looking at the incidence and prevalence of different mutational subtypes and their influence on response to tyrosine kinase inhibitors and the development of resistance. The results of this research will provide valuable insights which may influence future treatment approaches and is the basis for some very informative further GIST research. Thank you to all of our supporters for helping to raise the funds that have made this work possible!

IMPORTANT: PleaseProfessor Eamonn Maher can you help Professor Eamonn Maher with his Research Study?

We have received a request from Professor Eamonn Maher at the University of Cambridge asking if we can help him make contact with anyone who has had:

  • two or more primary GISTs or a GIST and another tumour, for inclusion in the multiple primary tumour study he is working on.

Though this combination of tumours is an uncommon event it can have several causes. Professor Maher and colleagues at the University of Cambridge are investigating how often this can be caused by inherited genetic changes.

They have requested that any GIST patients who fit the above criteria contact them directly for further information at: eamonn.maher@nhs.net

or write to: Prof. Eamonn Maher, Box 238, Addenbrooke’s Hospital, Cambridge Biomedical Campus, Cambridge CB2 0QQ. Participants will need to provide a blood sample and clinical information but the study does not require a visit to Cambridge.

Many thanks for your help, we hope that we will be able to help Professor Maher to help us!